Publications

2020

Virtakoivu R, Rannikko J, Viitala M, Vaura F, Takeda A, Lönnberg T, Koivunen J, Jaakkola P, Pasanen A, Shetty S, de Jonge M, Robbrecht D, Ma YT, Skyttä T, Minchom A, Jalkanen S, Karvonen MK, Mandelin J, Bono P, Hollmén M. Systemic blockade of Clever-1 elicits lymphocyte activation alongside checkpoint molecule downregulation in patients with solid tumors. MedRxiv doi: 10.1101/2020.11.11.20227777

Hollmén M, Figueiredo CR, Jalkanen S. New tools to prevent cancer growth and spread: a ‘Clever’ approach. BJC. 2020 Jun 29. doi: 10.1038/s41416-020-0953-0.

Felmerer G, Stylianaki A, Hollmén M, Ströbel P, Stepniewski A, Wang A, Frueh SF, Kim B-S, Giovanoli P, Lindenblatt N, Gousopoulos E. Increased levels of VEGF-C and macrophage infiltration in lipedema patients without changes in lymphatic vascular morphology. Scientific Reports. 2020 Jul 2;10(1):10947. doi: 10.1038/s41598-020-67987-3.

Jalkanen J, Hollmén M, Jalkanen S. Interferon beta-1a for COVID-19: critical importance of the administration route. Critical Care. 2020 Jun 12;24(1):335. doi: 10.1186/s13054-020-03048-5.

Jalkanen J, Pettilä V, Huttunen T, Hollmén M, Jalkanen S. Glucocorticoids inhibit type I IFN beta signaling and upregulation of CD73 in human lung. Intensive Care Med. 2020 May 19. doi: 10.1007/s00134-020-06086-3.

Felmerer G, Stylianaki A, Hägerling R, Wang A, Ströbel P, Hollmén M, Lindenblatt N, Gousopoulos E. Adipose tissue hypertrophy, an aberrant biochemical profile and distinct gene expression in lipedema. J Surg Res. 2020 May 11;253:294-303. doi: 10.1016/j.jss.2020.03.055

2019

Hollmén M, Zheng W, Pollard JW. Editorial: Targeting Myeloid Cells to Fight Cancer. Front Immunol. 2019 Dec 3;10:2835. doi: 10.3389/fimmu.2019.02835.

Z Ghazizadeh, TO Kiviniemi, S Olafsson, D Plotnick, M Beerens, K Zhang, L Gillon, M Steinbaugh, V Barrera, S Ho Sui, AA Werdich, S Kapur, A Eranti, J Gunn, J Jalkanen, J Airaksinen, AG Kleber, M Hollmén, CA MacRae. A Metastable Atrial State Underlies The Primary Genetic Substrate for MYL4 Mutation-Associated Atrial Fibrillation. Circulation, 16 Nov 2019, https://doi.org/10.1161/CIRCULATIONAHA.119.044268

A Takeda, M Hollmén, D Dermadi, J Pan, KF Brulois, R Kaukonen, T Lönnberg, P Boström, I Koskivuo, H Irjala, M Miyasaka, M Salmi, EC Butcher, S Jalkanen. Single-cell survey of human lymphatics unveils marked endothelial cell heterogeneity and mechanisms of homing for neutrophils. Immunity. 2019 17;51(3):561-572.e5. doi: 10.1016/j.immuni.2019.06.027.

S Tadayon, J Dunkel, A Takeda, O Halle, M Karikoski, H Gerke, P Rantakari, R Virtakoivu, O Pabst, M Salmi, M Hollmén*, S Jalkanen*. Clever-1 contributes to lymphocyte entry into the spleen via the red pulp. Science Immunology. 2019 Vol. 4, Issue 33, eaat0297. DOI: 10.1126/sciimmunol.aat0297. *equal contribution

M Viitala, R Virtakoivu, S Tadayon, J Rannikko, S Jalkanen, M Hollmén. Immunotherapeutic Blockage of Macrophage Clever-1 Reactivates the CD8+ T Cell Response Against Immunosuppressive Tumors. Clin Can Res. 2019 25(11):3289-3303. doi: 10.1158/1078-0432.CCR-18-3016.

2018

J Jalkanen, M Hollmén, M Maksimow, S Jalkanen, H Hakovirta. Serum cytokine levels differ according to major cardiovascular risk factors in patients with lower limb atherosclerosis. Cytokine 2018 Nov 13. pii: S1043-4666(18)30413-7.

J Dunkel, M Viitala, M Karikoski, P Rantakari, R Virtakoivu, K Elima, M Hollmén, Sirpa Jalkanen, Marko Salmi. Enhanced Antibody Production in Clever-1/Stabilin-1–deficient mice. Front. Immunol. 2018 Oct 8;9:2257.

E Munukka, J Ahtiainen, P Puigbo, S Jalkanen, K Pahkala, A Rintala, UM Kujala, M Hollmén, P Huovinen, G D’Auria, S Pekkala. Six-week endurance exercise alters gut metagenome that is not reflected in systemic metabolism in over-weight women. Front. Microbiol. 2018 Oct 3;9:2323 | https://doi.org/10.3389/fmicb.2018.02323

A Keskitalo, E Munukka, R Toivonen, M Hollmén, H Kainulainen, P Huovinen, S Jalkanen, S Pekkala. Enterobacter cloacae administration induces hepatic damage and subcutaneous fat accumulation in high-fat fed mice. PLoS ONE 2018, 30;13(5):e0198262. Doi: 10.1371/journal .pone.0198262.

P Rinne, JJ Kadiri, M Velasco-Delgado, S Nuutinen, M Viitala, M Hollmén, M Rami, E Savontaus, S Steffens. Melanocortin 1 Receptor Deficiency Promotes Atherosclerosis in Apolipoprotein E-/- Mice. Arteriosclerosis, Trombosis and Vascular Biology, 2018, Feb 38(2):313-323. doi: 10.1161/ATVBAHA.

2017

J Cui, M Hollmén, Li Lina, Y Chen, S Proulx, D Reker, G Schneider, M Detmar. New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate. Oncotarget, 2017 Jan 3;8(1):1007-1022. doi: 10.18632/oncotarget.13537.

J Jalkanen, M Hollmén, Sirpa Jalkanen, H Hakovirta. Regulation of CD73 in the Development of Lower Limb Atherosclerosis. Purinergic Signalling, 2017 Mar;13(1):127-134. doi: 10.1007/s11302-016-9545-0.

2016

S Vaara, M Hollmén, A-M Korhonen, M Maksimow, T Ala-Kokko, M Salmi, S Jalkanen, V Pettilä, The FINNAKI Study Group. Soluble CD73 in critically ill septic patients – data from the prospective FINNAKI study. PLoS ONE, 2016 Oct 12;11(10):e0164420. doi: 10.1371/journal.pone.0164420.

J Jalkanen, M Maksimow, M Hollmén, S Jalkanen, H Hakovirta. Compared to Intermittant Claudication Critical Limb Ischemia is Associated with Elevated Levels of Cytokines. PLoS ONE, 2016 Sep 9;11(9):e0162353. doi: 10.1371/journal.pone.0162353.

S Karaman, M Hollmén, S-Y Yoon, HF Alkan, K Alitalo, C Wolfrum, M Detmar. Transgenic overexpression of VEGF-C induces weight gain and insulin resistance in mice. Scientific Reports, 2016 Aug 11;6:31566. doi: 10.1038/srep31566.

AJ Christiansen, LC Dieterich, I Ohs, S Bachmann, R Bianchi, ST Proulx M Hollmén, D Aebischer, M Detmar. Lymphatic endothelial cells attenuate inflammation via suppression of dendritic cell maturation. Oncotarget 2016 Jun 5. doi: 10.18632/oncotarget.9820.

F Roudnicky, M Hollmén. Transcriptional profiling of macrophage and tumor cell interactions in vitro. Genomics data 2016, 8;1–3 doi:10.1016/j.gdata.2016.02.009 

2015 

M Hollmén, S Karaman, S Schwager, A Lisibach, AJ Christiansen, M Maksimow, Z Varga, S Jalkanen and M Detmar. G-CSF regulates macrophage phenotype and associates with poor overall survival in human triple-negative breast cancer. Oncoimmunology 11/2015, doi: 10.1080/2162402X.2015.1115177.

Li X, Martinez-Lozano Sinues P, Dallmann R, Bregy L, Hollmén M, Proulx S, Brown SA, Detmar M, Kohler M and Zenobi R. Drug Pharmacokinetics Determined by Real-Time Analysis of Mouse Breath. Angew Chem Int Ed Engl 2015, 4(27):7815-8. doi: 10.1002/anie.201503312. 

M Hollmén, F Roudnicky, S Karaman and M Detmar. Characterization of macrophage – cancer cell crosstalk in estrogen receptor positive and triple-negative breast cancer. Scientific Reports 3/2015 doi:10.1038/srep09188.

J Jalkanen, GG Yegutkin, M Hollmén, K Aalto, T Kiviniemi, V Salomaa, S Jalkanen, H Hakovirta. Aberrant Circulating Levels of Purinergic Signaling Markers are Associated with Several Key Aspects of Peripheral Atherosclerosis and Thrombosis. Circulation Research 2/2015 doi: 10.1161/CIRCRESAHA.116.305715.

2014

S Karaman, M Hollmén, MR Robciuc, A Alitalo, H Nurmi, B Morf, D Buschle, HF Alkan, AM Ochsenbein, K Alitalo, C Wolfrum and M Detmar. Blockade of VEGF-C and VEGF-D modulates adipose tissue inflammation and improves metabolic parameters under high-fat diet. Molecular Metabolism 12/2014; doi: 10.1016/j.molmet.2014.11.006.

GG Yegutkin, K Auvinen, P Rantakari, M Hollmén, M Karikoski, R Grénman, K Elima, S Jalkanen and M Salmi. Ecto-5′-nucleotidase/CD73 enhances endothelial barrier function and sprouting in blood but not lymphatic vasculature.. Eur J Immunol 7/2014 doi: 10.1002/eji.201444856.

M Karikoski, F Marttila-Ichihara, K Elima, P Rantakari, M Hollmén, T Kelkka, H Gerke, V Huovinen, H Irjala, R Holmdahl, M Salmi and S Jalkanen. Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis. Clin Can Res 10/2014 doi: 10.1158/1078-0432.CCR-14-1236.

He JJ, Martinez-Lozano Sinues P, Hollmén M, Li X, Detmar M and Zenobi R.  Fingerprinting Breast Cancer vs. Normal Mammary Cells by Mass Spectrometric Analysis of Volatiles. Scientific Reports 2014, 4:5196.

2013

N Valtcheva, A Primorac, G Jurisic, M Hollmén and M Detmar. The orphan adhesion G protein coupled receptor GPR97 regulates migration of lymphatic endothelial cells via the small GTPases RhoA and Cdc42. J Biol Chem 2013, 288:35736-48.

2012

M Hollmén, P Liu, K Kurppa, H Wildiers, I Reinvall, T Vahlberg, T van Dorpe, A Smeets, K Deraedt, H Joensuu, D Leahy, P Schöffski and K Elenius. Proteolytic processing of ErbB4 in breast cancer. PLoS ONE 2012, 7(6): e39413.

2005-2010

M Hollmén and K Elenius. Potential of ErbB4 antibodies for cancer therapy. Future Oncology 2010, 6:37-53, Review.

K Peltola, M Hollmén, S-M Maula, E Rainio, R Ristamäki, M Luukkaa, J Sandholm, M Sundvall, K Elenius, PJ Koskinen, R Grenman and S Jalkanen. Pim-1 kinase expression predicts radiation response in squamocellular carcinoma of head and neck and is under the control of epidermal growth factor receptor. Neoplasia 2009, 11:629-36.

M Hollmén, J Määttä, L Bald, MX Sliwkowski and K Elenius. Suppression of breast cancer cell growth by a monoclonal antibody targeting cleavable ErbB4 isoforms. Oncogene 2009, 28:1309-19. *patent

D Tvorogov, M Sundvall, K Kurppa, M Hollmén, S Repo, M Johnsson and K Elenius. Somatic mutations of ErbB4: selective loss-of-function phenotype affecting signal transduction pathways in cancer. J Biol Chem 2009, 284:5582-91.

Tanner M, Hollmén M, Junttila TT, Tommola S, Soini Y, Helin H, Salo J, Joensuu H, Sihvo E, Elenius K and Isola J. Amplification of HER-2 in gastric carcinoma: association with Topoisomerase IIalpha gene amplification, intestinal type, poor prognosis, and sensitivity to trastuzumab. Annals of Oncology 2005, 16:273-278.